Mains Answer Writing - 8 Oct, 2025

GS3

Science & Technology

10 marks

Discuss the significance of the discovery of regulatory T cells and the FOXP3 gene in understanding peripheral immune tolerance and its implications for treating autoimmune diseases and cancer.

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Tips for your answer

Define & Explain the Concept: Begin by clearly explaining what regulatory T cells and peripheral immune tolerance are, and how the FOXP3 gene plays a role in their function. This sets the conceptual base.
Discuss the Significance: Explain why these discoveries are important — how they help in preventing autoimmune diseases, maintaining immune balance, and shaping new medical therapies.
Link to Applications & Challenges: Conclude by connecting their relevance to modern therapies — like cancer immunotherapy and treatment for autoimmune disorders — and mention ongoing challenges such as balancing immune activation and suppression.

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