In the context of hereditary diseases, consider the following statements: 1. Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg. 2. A child inherits mitochondrial diseases entirely from mother and not from father. Which of the statements given above is/are correct?

QUESTION

Medium

Science & Technology

Prelims 2021

In the context of hereditary diseases, consider the following statements:

Passing on mitochondrial diseases from parent to child can be prevented by mitochondrial replacement therapy either before or after in vitro fertilization of egg.
A child inherits mitochondrial diseases entirely from mother and not from father.

Which of the statements given above is/are correct?

Select an option to attempt

Explanation

Statement 1 is correct. Mitochondrial replacement therapy (MRT) is a reproductive technique used to prevent the transmission of mitochondrial diseases from mother to child. It involves replacing defective mitochondria in an egg or embryo with healthy mitochondria from a donor. MRT can be performed either before or after in vitro fertilization to ensure that the resulting embryo does not inherit mitochondrial diseases.

Statement 2 is correct. Mitochondrial DNA (mtDNA), which is responsible for encoding genes essential for mitochondrial function, is inherited exclusively from the mother. Therefore, mitochondrial diseases caused by mutations in mtDNA are passed down maternally, and a child cannot inherit mitochondrial diseases from the father.

Therefore, both statements are correct.

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