Mains Answer Writing - 3 Dec, 2025
GS3
Science & Technology
15 marks
Discuss how hypoxia-induced changes in plasma membrane lipids influence the metastatic potential of pancreatic cancer cells. What implications does this have for future cancer therapies?
Tips for your answer
- Start with the core concept – explain hypoxia and how it alters plasma membrane lipids in cancer cells.
- Link changes to behaviour – briefly show how lipid modulation affects stiffness, malleability, and migration/metastasis.
- End with implications – mention therapeutic targets, role of lipidome studies, and potential for precision cancer treatment.
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GS3
Environment & Ecology
21 Apr, 2026
“The crisis of the Colorado River reflects a shift from hydrological scarcity to ecological water loss.”
Discuss the geographical features of the Colorado River system and critically examine the role of climate change and ecological processes in altering river flows. - View Challenge
GS2
Indian Polity
Yesterday
“India’s migration governance remains reactive and fragmented rather than continuous and worker-centric.”
Discuss the key challenges in India’s migration governance architecture. Suggest measures to build a comprehensive and resilient migration management system. - View Challenge
GS2
Indian Polity
19 Apr, 2026
Custodial deaths reflect deeper structural issues in India’s policing system.
Discuss the causes of custodial violence and suggest measures to ensure accountability and protection of human rights.
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