The 5 family members are A, B, C, D, and E. The given statements are:

Statement 1: A and B are a married couple. Statement 2: D is the father of C. Statement 3: E is D's son. Statement 4: A and C are sisters.

We need to find the relation of E with B. We must use statements 1 and 3, as B and E have not been mentioned in any other statement.

Option (A): Statements 1, 2 and 3 alone are not sufficient, as we cannot find a link between B and E in these statements.

Option (B): Statements 1, 3 and 4 alone are not sufficient, as we cannot find a link between B and E in these statements.

Option (C): Using all the four statements, we get the following family tree:

So, E is the brother-in-law of B.

Hence, option (C) is correct.