To find the value of X in the sequence 2, 12, 36, 80, 150, X, let's break down each number in the sequence:

First term: $1 \times 1 \times 2 = 2$ Second term: $2 \times 2 \times 3 = 12$ Third term: $3 \times 3 \times 4 = 36$ Fourth term: $4 \times 4 \times 5 = 80$ Fifth term: $5 \times 5 \times 6 = 150$

The pattern is clear: each term in the sequence is the product of three consecutive integers. Therefore, to find the next term, we apply the same pattern:

Sixth term: $6 \times 6 \times 7 = 252$

Thus, the value of X is 252.

Hence, the correct answer is 252.