Protein in blood could be ‘universal’ ageing marker, Pg10

Key Highlights:

• Scientists identified neurofilament light chain (NfL), a protein in blood, as a potential universal marker for ageing.
• NfL levels consistently rise with age in humans, mice, cats, dogs, and horses.
• Longer-lived species exhibit lower starting NfL levels.
• A blood test measuring NfL could potentially assess an individual's ageing rate.

Detailed Insights:

• NfL leaks from nerve cells into the blood as the body ages, making it a measurable indicator.
• The consistent correlation between age and NfL levels across diverse species strengthens its potential as a universal ageing marker.
• Measuring NfL levels could offer insights into age-related diseases and interventions.
• Further research is needed to validate NfL as a reliable biomarker and understand its relationship with various health outcomes.

Scientific/Technical Concepts Involved:

• Neurofilament light chain (NfL): A structural protein found in nerve cells that is released into the blood upon nerve damage.
• Biomarker: A measurable indicator of a biological state or condition, such as ageing or disease.